Monday, April 27, 2009

Researchers Use Stroke Patient’s Own Stem Cells For First Time


Thursday, April 16th, 2009

For the first time in the United States, a stroke patient has been intravenously injected with his own bone marrow stem cells as part of a research trial at The University of Texas Medical School at Houston.

Roland "Bud" Henrich, 61, was transferred to Memorial Hermann – Texas Medical Center on March 25 after suffering a stroke while working on his farm in Liberty. He arrived too late to receive tissue plasminogen activator (tPA), the only treatment for ischemic strokes. He became the first patient in the trial.

The Phase I safety trial, funded with a pilot grant from The National Institutes of Health and support from the Notsew Orm Sands Foundation, will enroll nine more patients who have suffered a stroke and can be treated with the stem cell procedure within 24 to 72 hours of initial symptoms.

Stroke occurs when blood flow to the brain is interrupted by a blockage or a rupture in an artery, depriving brain tissue of oxygen. It is the third-leading cause of death behind heart disease and cancer. According to the American Stroke Association, nearly 800,000 Americans suffer a stroke each year – one every 40 seconds. On average, someone dies of stroke every three to four minutes.

"It's still very early in this safety study, but this could be an exciting new therapeutic approach for people who have just suffered a stroke," said Sean Savitz, M.D., assistant professor of neurology at the medical school and the study's lead investigator. "Animal studies have shown that when you administer stem cells after stroke, the cells enhance the healing. We know that stem cells have some kind of guidance system and migrate to the area of injury. They're not making new brain cells but they may be enhancing the repair processes and reducing inflammatory damage."

Savitz said animal studies have shown that the healing effects of stem cells can occur as early as a week but cautioned it is too early to attribute Henrich's improvement to the stem cell treatment. "I'm hoping he will get better and it will be because of the cells, but it's just hope at this point," Savitz said.

The stem cells were harvested from the bone marrow in the iliac crest of his leg, then separated and returned to Henrich several hours later. Because they are his own stem cells, rejection is not expected to be an issue.

When he arrived at the hospital, Henrich could not speak and had significant weakness on his right side. When he was released after nearly two weeks of hospitalization and rehabilitation, he was able to walk and climb stairs unassisted and said his first words.

His wife, Reba Henrich, said she believes the stem cells have helped. He has spoken a few times with a single word or a phrase since his return home. "Too crowded," he told her at a megastore as they shopped for Easter gifts for their grandchildren and "senior" meal he told a waitress at a local restaurant. He also has fed the cows by himself, she said. They are hopeful he will eventually be able to return to his job as a painter.

"This study is the critical first step in translating laboratory work with stem cells into benefit for patients. If effective, this treatment could be helpful to a huge segment of stroke patients to reduce their disability," said James C. Grotta, M.D., Roy M. and Phyllis Gough Huffington Distinguished Professor of Neurology and chair of the Department of Neurology at the medical school. "We are fortunate here at UT Houston and the Texas Medical Center to have the resources needed to carry out this work, and to have attracted someone of Dr. Savitz's caliber to lead this study."


University of Texas Health Science Center at Houston: http://www.uthouston.edu

Thanks to University of Texas Health Science Center at Houston for this article.

This article was found on Lab Spaces has been viewed 274 times.

Monday, April 20, 2009

Note to Ben, June & Debra

This blog is just a sample for you all to check over. I thought it would be a good idea to make it really easy to share information with everyone, have it all in one place and create a way that everyone can share, report, or send in messages. It turns out that there is a very good network set up for just the purpose of keeping people connected during medical emergencies and it's called Caring Bridges.

It's set up the same as a blog, although more specifically for patients & families, and it may be a better way to share Sophie's progress with everyone you want. I'll look into what's involved in creating a webpage there for you. You may want to have both, one place where we can exchange information, research, etc. and another place where you'all can post and follow Sophie's day-to-day progress.

Ben, if you'd like for June or Debra to take over the 'computer' end of it, just send me their email addresses. But don't be intimidated by the technology--it can be easily learned, and you'll wonder how you managed without it once you know it!

Twitter
is also a great way that people stay in touch moment to moment because it uses text messaging and I can show you how to do this if you're interested. My kids keep me techno-savvy, but trust me, it's not very complicated!

Please give Sophie my best. When do you think that she'll be ready for a visit?

Saturday, April 18, 2009

My Stroke of Insight

Jill's vivid description of her stroke may give us a tiny insight into what Sophie experienced when she had hers. Warning: you may need some Kleenex...

Jill Bolte Taylor got a research opportunity few brain scientists would wish for: She had a massive stroke, and watched as her brain functions -- motion, speech, self-awareness -- shut down one by one. An astonishing story on TED.com




Inspiration of Bach-y-Rita's career

Click on the text to read from the book, The Brain That Changes Itself by Norman Doidge.

Vilayanur Ramachandran: A journey to the center of your mind

Really interesting speaker!


The Power of Plasticity

The dogma used to be that the adult brain was a rigid, unchangeable organ, but that pessimistic perspective is now being radically revised. Psychiatrist Dr Norman Doidge journeyed into the labs and lives of the 'neuroplasticians' -- once scientific mavericks, they're challenging the old neurological nihilism. Professor Jeffrey Schwartz is one. They both join Natasha Mitchell in discussion to reveal how the human brain has underestimated itself! Listen to the podcast, The Power of Plasticity part 1 .

The brain is more plastic than scientists once believed. But what does this mental malleability mean for humanity? More compelling stories from psychiatrist Dr Norman Doidge as he enters the labs and lives of the new 'neuroplasticians'. Here you will hear more about the Bach-y-Rita brothers and their findings in The Power of Plasticity, part 2.